Selective loss of pyramidal neurons in the pre‐supplementary motor cortex in Parkinson's disease
Identifieur interne : 001837 ( Main/Exploration ); précédent : 001836; suivant : 001838Selective loss of pyramidal neurons in the pre‐supplementary motor cortex in Parkinson's disease
Auteurs : Virginia Macdonald [Australie] ; Glenda M. Halliday [Australie]Source :
- Movement Disorders [ 0885-3185 ] ; 2002-11.
English descriptors
- KwdEn :
Abstract
The nonprimary motor cortices have not previously been studied in Parkinson's disease, despite the selective pattern of dysfunction observed in these regions. In particular, the pre‐supplementary motor region is consistently underactive, with successful treatments correlating with increased excitatory drive to nonprimary motor regions. This finding could suggest a primary cortical abnormality in the pre‐supplementary motor area (pre‐SMA) in Parkinson's disease. We analysed and compared neuronal number in the pre‐SMA and dorsolateral premotor cortical regions in 5 cases of Parkinson's disease and 5 controls. For each cortical region, the total neuronal number as well as the estimated numbers of subpopulations of interneurons and pyramidal neurons was quantified using previously published unbiased techniques. The results showed a significant loss of cortico–cortical projecting pyramidal neurons in the pre‐SMA with no loss of other pyramidal neurons or interneurons either in this region or in the dorsolateral premotor region. These findings indicate a highly selective loss of pyramidal cells in the pre‐SMA in Parkinson's disease, consistent with previous imaging findings in this disease. Our results implicate the degeneration of the premotor projection from the pre‐SMA, along with dopaminergic basal ganglia dysfunction, in the pathogenesis of Parkinson's disease. © 2002 Movement Disorder Society
Url:
DOI: 10.1002/mds.10258
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Selective loss of pyramidal neurons in the pre‐supplementary motor cortex in Parkinson's disease</title><author><name sortKey="Macdonald, Virginia" sort="Macdonald, Virginia" uniqKey="Macdonald V" first="Virginia" last="Macdonald">Virginia Macdonald</name></author><author><name sortKey="Halliday, Glenda M" sort="Halliday, Glenda M" uniqKey="Halliday G" first="Glenda M." last="Halliday">Glenda M. Halliday</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D98DB6CCFDFB2AE6236619C791C47CC25B22B1B7</idno><date when="2002" year="2002">2002</date><idno type="doi">10.1002/mds.10258</idno><idno type="url">https://api.istex.fr/document/D98DB6CCFDFB2AE6236619C791C47CC25B22B1B7/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002D90</idno><idno type="wicri:Area/Main/Curation">002A11</idno><idno type="wicri:Area/Main/Exploration">001837</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Selective loss of pyramidal neurons in the pre‐supplementary motor cortex in Parkinson's disease</title><author><name sortKey="Macdonald, Virginia" sort="Macdonald, Virginia" uniqKey="Macdonald V" first="Virginia" last="Macdonald">Virginia Macdonald</name><affiliation wicri:level="3"><country xml:lang="fr">Australie</country><wicri:regionArea>Prince of Wales Medical Research Institute and the University of New South Wales, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement></placeName></affiliation></author><author><name sortKey="Halliday, Glenda M" sort="Halliday, Glenda M" uniqKey="Halliday G" first="Glenda M." last="Halliday">Glenda M. Halliday</name><affiliation wicri:level="3"><country xml:lang="fr">Australie</country><wicri:regionArea>Prince of Wales Medical Research Institute and the University of New South Wales, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="2002-11">2002-11</date><biblScope unit="volume">17</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="1166">1166</biblScope><biblScope unit="page" to="1173">1173</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">D98DB6CCFDFB2AE6236619C791C47CC25B22B1B7</idno><idno type="DOI">10.1002/mds.10258</idno><idno type="ArticleID">MDS10258</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>calcium binding proteins</term><term>immunohistochemistry</term><term>interneurons</term><term>motor cortices</term><term>non‐phosphorylated neurofilament</term><term>pyramidal neurons</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The nonprimary motor cortices have not previously been studied in Parkinson's disease, despite the selective pattern of dysfunction observed in these regions. In particular, the pre‐supplementary motor region is consistently underactive, with successful treatments correlating with increased excitatory drive to nonprimary motor regions. This finding could suggest a primary cortical abnormality in the pre‐supplementary motor area (pre‐SMA) in Parkinson's disease. We analysed and compared neuronal number in the pre‐SMA and dorsolateral premotor cortical regions in 5 cases of Parkinson's disease and 5 controls. For each cortical region, the total neuronal number as well as the estimated numbers of subpopulations of interneurons and pyramidal neurons was quantified using previously published unbiased techniques. The results showed a significant loss of cortico–cortical projecting pyramidal neurons in the pre‐SMA with no loss of other pyramidal neurons or interneurons either in this region or in the dorsolateral premotor region. These findings indicate a highly selective loss of pyramidal cells in the pre‐SMA in Parkinson's disease, consistent with previous imaging findings in this disease. Our results implicate the degeneration of the premotor projection from the pre‐SMA, along with dopaminergic basal ganglia dysfunction, in the pathogenesis of Parkinson's disease. © 2002 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Australie</li></country><settlement><li>Sydney</li></settlement></list><tree><country name="Australie"><noRegion><name sortKey="Macdonald, Virginia" sort="Macdonald, Virginia" uniqKey="Macdonald V" first="Virginia" last="Macdonald">Virginia Macdonald</name></noRegion><name sortKey="Halliday, Glenda M" sort="Halliday, Glenda M" uniqKey="Halliday G" first="Glenda M." last="Halliday">Glenda M. Halliday</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001837 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001837 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:D98DB6CCFDFB2AE6236619C791C47CC25B22B1B7
|texte= Selective loss of pyramidal neurons in the pre‐supplementary motor cortex in Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |